The Fortyfive Squared Hotel was born inside an 1870s building, and is the historical memory of the then Servadio Palace, of which remains the last portion occupied precisely by the current Hotel.
Servadio Palace was designed by Enrico Kleffler around 1870 for the Honorable Giacomo Servadio, a Florentine banker and president of the Società Generale Credito Immobiliare e Costruzione, which was commissioned to build the new Macao district. It was one of the first buildings to be erected in the Square in 1872.